Solid Dosage Production Line

30kg Per batch Solid Dosage Granulation and Drying Production Line

Product ID: Solid Dosage Production Line
Brand Name: Liangke
Certification: CE,GMP,ISO
Price: negotiable
Payment Terms: TT,L/C,West Union
Delivery Time: 30 working days upon receipt of payment
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30kg Per batch Solid Dosage Granulation and Drying Production Line
This production line is designed for the small scale solid dosage around 30kg, it is combined from the HLSG100 High efficiency wet granulator, SZ300 wet sieving and milling machine, FL30 Fluid bed granulating dryer. It is suitable for the small scale production of solid dosage product.

HLSG-series High Efficiency Wet Granulator

Overview
Our company, as a company specialized in the development, manufacture, sale and service of pharmaceutical machine, is awarded as a creditable enterprise , and rated as Credit A company. Some other awards are “ Developing Technical SME in Zhejiang Province”, “Technical SME in Zhejiang Province”, “Technical (Innovative) Enterprise in Wenzhou”. Besides, Our equipments have passed the CE Qualification Certification of EU. In addition, our machines are sold to many provinces and cities of China and to parts of America, Europe, Oceania, West Asia and South-east Asia.

HLSG series high efficiency wet granulator is a newly developed machine of granulation. It can finish all processes of mixing, wetting, and granulation. What’s more, it has high production efficiency and good granulation effect and can comply with GMP requirements.

It is a machine of light, electricity and gas, and applies Siemens PLC for control, HMI and touch screen for display and operation, and continuously variable frequency control, photoelectrical detection and control and other advanced technologies. Besides, some other equipments are innovated, including adhesive feeding device, automatic securing device, jacket cooling and temperature controlling system. Therefore, the machines acquire perfect functions and high automation, save adhesive and can operate in a short time but produce granules of good quality. With high pelletizing rate, the machines can mix every kinds of powders and ointments to solid pellets of uniform diameters. Therefore, they can be used in many fields, namely, pharmacy, foodstuff, chemicals and metallurgy, for mixing and granulation. Particularly, they can be used to mix and granulate Chinese medical extract and Chinese medical powders, which provides a solution for the technical difficulty of changing Chinese medical herb to medicine.

Operation Principle

This machine consists of machine frame, double-layered pot, pot cover, mixing shaft, cutter, material outlet port, feeding device, flying cutter transmission, mixing transmission, cooling system, automatic control system, etc..

This machine uses the jacketed pot as material container, and mixing revolving and cutters revolving as power. After setting time and rotating speed and starting the machine, the mixing shaft will mix material with set rotating speed; then adhesive will be fed through the material feeding device to be mixed and granulated with material in a short time; next high rotating speed cutter will cut off material (the rotating speed of mixing shaft and cutter can be adjusted to produce qualified granules of different diameters); at last the material outlet port can be opened to output granules automatically.

Main Technical Parameters

Model and specification	HLSG-100
Hopper capacity	100L
Material feeding volume	30-80L
Operation time	5min/batch for mixing 3-15min/batch for granulation
End product diameter	About Φ0.10-Φ2.5mm
Mixing motor	7.5KW, 6 poles
Rotating speed of mixing shaft (frequency control)	30-250rpm
Granulating motor	3KW, 2 poles
Rotating speed of granulating shaft (frequency control)	50-3000rpm
Compressed air	0.3m3, 0.7MPa
Cooling water connector	Φ8mm
Compressed air port	Φ8mm
Overall dimensions (LBH)	17606001660mm
Weight	About 800Kg

LJY-30 Automatic Liquid Feeding System

It is the automatic liquid feeding system which will transfer the liquid product into the wet granulation machine automatically to realize a continuous feeding and full automatic production line, which will help to save labor cost and brings a higher efficiency.

Technical Parameters

Model	LJY-30
Operation volume	30L
Mixing rotating speed (pneumatic mixing)	10-300rpm
Air consumption	0.3-0.5m3/h
Overall size of bucket	350*450
Operation air pressure	0.4-0.6MPa
Machine weight	50Kg

SZ Series Wet Sieving and Milling Machine

sz series of wet sieving and milling machine is mainly used in industries of pharmacy, foodstuff and fine chemical processing and complies with GMP requirements. Besides, the machine is completely made of stainless steel.

Working principle:

After entering the material inlet port of wet sieving and milling machine, raw material will fall into the cone operation chamber. Then the material will form to swirling flow under the function of flying cutters and be pushed toward the screen net by centrifugal force. Meanwhile, the high-speed revolution of flying cutters can take shearing action with screen net so that the material will be smashed into small granules between the flying cutters and screen, and then discharged through screen mesh. The size of smashed granules can depend on the screen meshes, the gap between flying cutters and screen and the rotating speed of flying cutters.

There are two discharging methods as below:

A. Direct connection (the discharge port of wet sieving and milling machine and the material inlet port of fluid bed granulating / drying machine are connected directly by a delivery hose).

A. Direct connection for granule discharging

Install a discharging device under the barrel of wet sieving and milling machine and connect its discharge port with a delivery hose. Under the negative pressure in fluidization cavity of fluid bed granulating / drying machine, the wet granules enter into the fluid bed directly through the delivery hose for drying. (With the pneumatic suction force to convey the material)

The advantages of A discharging method: the materials during the whole process from granulating to drying are in an airtight system, which is a real sense of super-clean production (SCP) mode.

B. Direct drop (the wet materials after pelletzing drop into the strorage container or the hopper of fluid bed granulating / drying machine).

Main Technical Parameters

Item Mode		SZ-300
Motor power	KW	3.7
Production capacity	Kg/h	50-200
screen mesh size	Mm	22－66（choose any one）
Revolution speed	rpm	The maximum speed can be regulated to 1600 by frequency converter.
Revolution speed of cutter	rpm	200~1600
Screen net shape for cutter	Square: suitable for wet granules sieving and milling

FL-30 Fluid Bed Granulating Dryer

1. Application

Fluid-bed processing is mainly used to granulate and dry medical granules in pharmaceutical, foodstuff, chemical, agricultural and sideline product processing industries, such as granules for tablet, instant powder and condiment granules. The process of feeding and discharging material of this equipment should be finished in the airtight space to avoid powder spreading to the operation environment. It‘s controlled by PLC to granulate and dry in fluid bed.

Brief introduction to top spray system

Top spray system consists of a cone material tank and diffusion (spraying) chamber. The processing airflow passes through the airflow distribution board and screen net from the tank bottom to this equipment. When the flow rate of inlet air overcomes its gravitational force, the material in tank can form eddy flow (fluid bed).

1.The inlet airflow from the bottom up will push the material in the tank to move upward. As with a certain angle of the tank, the aggregative fluidization of the material in it is very intense.

2.The material pushed by the airflow enters the diffusion chamber. As the space of diffusion chamber is larger than that of tank, the airflow velocity in chamber will be lower than that in tank and the speed of material granules in chamber will decrease. When the gravity force of granule itself overcomes the pushing force of inlet airflow from the bottom up, it will fall down and return to the edge area of tank. During the whole process, the granules will move back and forth between diffusion chamber and tank to form irregular fluidization.

3.The aim of granulating is to produce dust-free and flexible granules with fine powders.

4.When granulating with top spray device of fluid bed, the powder or granules rise from the tank bottom in fluidized state; the adhesive is sprayed to the fluid bed by the nozzle of spray gun installed on the diffusion (spraying) chamber for granulation. Material can be dried through the heat exchange occurring between the hot airflow entering form the bottom and the heated airflow distribution board.

5.In the phase of material being blown by air, the surface of each granule will be fully exposed to the airflow so that the best atomizing spray medium and drying result can be achieved.

6.The top spray technique is applicable for granulation and drying. After dismantlement of the spray gun in diffusion (spraying) chamber, the top spray device turns to be a fluid bed drier.

Technical Parameters

Item Parameter			FL-30 fluid bed dryer
Material container	Volume	L	110
	Diameter	M	750
Production capacity		Kg/time	15-30
Power supply		Three-phase	380V/50HZ
Electrical heating power		Kg	27
Compressed air	Pressure	MPa	0.4-0.7
	Consumption	Kg/h	0.5
fan	Power	Kw	11
Material temperature		℃	Auto-control and auto-display
Application			Applicable to produce and dry Chinese medicine, medical granules, tablet granules, capsule granules
Yield rate		%	≥99%
Product moisture		%	1%-5% after drying
Noise		db	Less than 75db since fan is separated
Material		Stainless steel for all the machine and SUS304 for surface with matte treatment, mirror-polish until Ra 0.3-0.5 inside.
Sealing mode		Cylinder top sealing of good effect
Air inlet filter		With primary, medium and sub-high efficiency filters, so the air filtration level reaches 100000 grade (3μm).
Airflow control		Frequency control
Heater		Heating mode: electrical heating / Heating material: SUS#304
Control method		PLC control, frequency converter regulating the air capacity, touch screen operating system, Chinese operation interface.
GMP		Designed and produced under requirements of GMP to comply with them
Product standard		JB/T13755-92
Noise		db	Less than 75db since fan is separated
Overall dimensions		Seen in the installation floor plan

Brief introduction of CIP one-way cleaning system

The cleaning machine consists of main frame, water pipeline, cleaning ball, high-pressure booster pump, control valve and control system. After quick-connection of the water inlet of cleaning machine with customer’s water inlet pipe, the cleaning procedure can be started to finish this process automatically.