Solid Dosage Production Line

60-70Kg per Batch Solid dosage production line

Product ID: Solid Dosage Production Line
Brand Name: Liangke
Certification: CE,GMP,ISO
Price: negotiable
Payment Terms: TT,L/C,West Union
Delivery Time: 30 working days upon receipt of payment
INQUIRY

60-70Kg per Batch Solid dosage production line
This is a small scale production line for solid dosage product, it is combined of HLSG 300 wet granulation machine,SZ-300 wet type pelletizer ,FL 60 model fluid bed drying machine and some other optional equipment as per the requirement of different customer, such as vacuum feeder, top, side and bottom spraying, and CIP one way cleaning system.

HLSG-series Wet granulation Machine

Overview

HLSG-series wet granulation machine is a new generation of granulating equipment recently developed by our company, which can realize the following working procedures including mixing, wetting, granulating at one time. It is featured with effective granulation and in strict compliance with GMP requirement.

It adopts Siemens PLC micro-computer control, human machine interface and touch screen to display the operations. The temperature, operating time, speed and formula are input to micro-computer and auto-controlled according to procedures, easy to operate with high automatic degree.

Add a set of V shape cutters on the basis of traditional straight shank cutter so that the cutters can action in both horizontal and vertical directions in material cutting process, which can reduce the granulating time. Cooperating with the unique mixing paddle of this machine, it’s helpful to scrape away the attachment inner container to reduce the material sedimentation around container in-wall & at bottom and the collision to in-wall, at the same time, improve granulating efficiency and pelletized ratio, reduce the fine powder content below 8%. It adopts jacketed pot technique, which can heat or cool the material as required. The temperature in tank can be regulated by micro-computer automatically with temperature departure less than ±20C.

Provide the dripping device together with this machine. The adhesive addition can adopt dripping or direct mixing ways according to different requirements for different medicines, which can save around 20% consumption of adhesive, good effect of mixing granulation.

The safety protection device is complete and reliable. When the pot cover is under opening status, the main machine can only be started to operate by password and can’t be started by other people so that ensure the safety of operators and machine. It can reserve vacuum feeding port at the part of pot cover, at the same time, equip with dedusting unit and adhesive filling port. We can monitor the granulating status in different stages through the sight glass to realize the non-dust operation in granulating process.

The cutter and revolving shaft of mixing paddle adopt double composite technology of rubber gasket with oil and spiral with air to seal, which completely solve the big problem of shaft seal easy to fail. The shaft seal is made into pulling type and can be dismounted, easy to maintain.

The mixing and granulating can be finished with one step, increasing the efficiency 4-5 times. The finished granules are solid with uniform size and high pelletized ratio. The granule size and bulk density can be adjusted optionally, suitable for the mixing granulation of Chinese herbal powders with big difference between chief herb and ingredients, Chinese medical extract, achieving good result.

Main Technical Parameters

Model and specification	HLSG-200
Hopper capacity	200L
Working capacity	80-150L
Operational time	Mixing about 2 minutes granulating about 7-14 minutes each batch
Finished product granularity	About Φ0.14-Φ1.5mm(12 holes-100 holes)
Mixing motor	15KW 6 poles
Mixing blade rotating speed (Frequency conversion speed-adjusting)	30-250 R/Min
Granulating motor	4KW 2 poles
Granulating blade rotating speed (Frequency conversion speed-adjusting)	50-3000 R/Min
Compressed air	0.3 m3 0.7Mpa(Collocated by customer themselves)
Cooling water connecting	Φ10mm
compressed air ora	Φ10mm
Height of material outlet (mm)	920mm
Overall dimension of main machine (L×B×H)	2270×910×2010mm
Weight	1200kg

SZ Series Wet Type Pelletizer

SZ series of wet type pelletizer is mainly used in pharmaceutical, food and fine chemicals processing industries, a kind of wet processing equipment to palletize material, which can link with other devices, in accordance with GMP requirements. The whole machine is made by stainless steel.

Working principle

Working principle: after the raw material to be processed entering the feeding inlet of wet type pelletizer, they will fall into the cone-shaped working chamber. Then the raw material will form to swirling flow under the function of flying cutters and be pushed toward the screen net surface by centrifugal force. As the high-speed revolution of flying cutters can take shearing action with screen net surface, the material will be smashed into small granules between the flying cutters and screen, and then discharged through screen mesh. The size of smashed granules can be adjusted by the screen meshes, the gap between flying cutter and screen and the revolution speed of flying cutters.

There are two discharging methods as below:

A. Direct connection (the discharge port of wet type pelletizer and the feed inlet of fluid bed granulating / drying machine are connected directly by a delivery hsoe).

B. Direct drop (the wet materials after pelletzing drop into the strorage container or the hopper of fluid bed granulating / drying machine).

A. Direct connection for granules discharging

Install a discharging device under the barrel of wet type pelletizer and connect its discharge port with a delivery hose. Under the negative pressure in fluidization cavity of fluid bed granulating / drying machine, the wet granules enter into the fluid bed directly through the delivery hose for drying. (With the suction type pneumatic force to convey the material)

The advantages of A discharging method: the materials during the whole process from granulating to drying are in an airtight system, which is a real sense of super-clean production (SCP) mode.

B. Direct drop for granules discharging

Place a container under the barrel of wet type pelletizer, which can be the hopper of fluid bed granulating / drying machine. The wet granules after pelletizing fall into the container directly and then be transmitted to drying machine or drying cabinet to be dried.

The advantages of B discharging method: more flexible for the coordination of the whole granulating system, in favor of improving the rate of granulating equipment utilization.

SZ-300 Wet Type Pelletizer

Technical Parameters

Model	SZ-300
Motor power（KW）	3.7
Production capacity（Kg/h）	50-300
screen mesh size（Mm）	2×2－8×8（choose any one）
Revolution speed（rpm）	The maximum speed can be regulated to 1400 by frequency converter.
Revolution speed of cutter（rpm）	200~1400
Screen net shape	Square: suitable for wet granules pelletizing

FL-60 Fluid Bed Granulating Drier

Machine Photo

Application

Fluid-bed processing is mainly used for the mixing of powder material, drying and granulating (coating) in pharmaceutical, food, chemical, agricultural and sideline product processing industries, such as tablet, instant powder and condiment granules. The process of feeding and discharging material for this equipment should be finished in the airtight space to avoid powder spreading to the working environment. It‘s controlled by PLC. For wet type granulating machine, it adopts negative pressure or air blast to make the finished granules enter the fluid bed for drying in airtight way.

Working principle

The air flow sucked by the negative pressure of induced draught fan will pass through the air filter, heat exchanger and delivery conduit, finally enter the fluid bed granulating room from the airflow distribution board to blast the raw powder (such as original powder, Polybutene, absorbent, western medicine or food etc.) into boiling fluidized state and start mixing at the same time.

Liquid material and the compressed air for atomizing liquid material enter the sprayer along their respective pipes. The compressed air atomizes the liquid material into fine particles to spray in the fluid bed granulating room, and then mix with raw powder to bond into granules. At the same time, the granules will be dried by hot air and a part of powder rises to the filter bag to be collected. At a certain time, the left exhaust valve closes and the filter bag in left chamber shakes up and down under the action of air cylinder; the powder being shaken off then falls back to the fluid bed to granulate again. After shaking, the left exhaust valve opens again; after a while, the right exhaust valve closes and the filter bag in right chamber shakes.

The filter bags in both chambers shake alternatively to clean the collected powder to keep the filter bag unblocked and finish the process of mixing, drying and granulating.

Unique Advantages

1. Equipment Height

It's higher than normal ones, the cloth bag not easy to be wet and blocked. Materials can be dried completely, drying speed is high, energy consuption is low.

2. Distribution Net

The distribution net between air intake chamber and material chamber are multi-layer, which is rigid, high temperature resistant and not easy to be deformed. Quick installation, quick dismantlement and easy to be cleaned.

The conventional ones have only two layers, a thin piece of stainless steel wire net on a punched plate. Hard to be cleaned, easily broken and transformable. Materials can not dried completely and homogeneously.

3. The insulating layer thickness of the heating cabinet

Insulating layer of the heating cabinet is added to anti-scald and reduce energy consumption. In addition, openable doors adopted, convenient for changing accessories, cleaning and maintenance.

4. Air inlet proportion execution valve and air outlet pneumatic execution valve

These two valves equiped, bag shaking system can be closed tightly to get a good dedusting effect.

5. Steam proportion valve is equipped

Temperature can be kept around the set value (about ±2°C), which is good for maintaining the medical stability and saving steam energy. Only 1/3 energy consumption when the set temperature reached.

6. Pressure relief device - the top relief valve

The fluidized bed chamber is in a state of negative pressure normal production, if it is in positive state then pressure will be relieved from the pressure relief port to avoid explosion and other unexpected accidents.

7. Bag shaking device

The bag shaking device is divided into two parts, left and right ones with many small cloth bags, and with continuously shaking and dedusting function.

The more cloth bags are designed, the larger area can be used for filter and dry, high efficiency, fast speed, time and energy saved. While, normal machine only has a one-piece shaking bag without any small bags. Bags can be shook only after the machine stops. Low efficiency, slow drying speed, long time and large energy wasted. Besides, our bag shaking device has a pneumatic location device to fix and protect bags for better dust removal effect. And the bottom of the device extends to the outside of the chamber to guarantee practicality. Some other factories’ apply gas seal at the device bottom, but after a long time of high temperature operation, the chamber will transform and sealing will not be tight any more. Therefore, material will be run off and great loss will be caused.

8. Observation light is installed in the chamber

Compared with other manufacturers, it is in the outside, the operation and drying conditions inside the chamber cannot be observed clearly.

9. Moreover, according to different countries geographically location (in humidity) and different environmental requirements, dehumidification and second dust removal system can be adopted to achieve their requirements of material, techniques and environment protection.

Main Technical Parameters

Item Parameter			FL-60 Fluid Bed Granulating and Coating Machine
Production capacity		Kg/time	10-70
Power supply		Three-phase	380V/50HZ
Electrical heating	power	Kw	70
	Consumption	Kg/h	25
Compressed air	Pressure	MPa	0.4-0.7
	Consumption	Kg/h	1.2
Draught fan	Power	Kw	15
Material temperature		℃	Auto-control and auto-display
Application range			Mainly used for producing and drying the instant granules, tablets and capsules in both Chinese and western medicines.
Obtaining ratio		%	≥99%
Product moisture		%	Can reach 5‰-5% after drying
Noise		db	With isolating treatment, the noise of draught fan is less than 75 dB.
Material		Stainless steel for all the machine and SUS304 for surface with matte treatment, mirror-polish until Ra 0.3-0.5 inside.
Sealing type		Head pressure type with pneumatic cylinder, good sealing effect.
Filtration of inlet air		It’s equipped with primary, medium and sub-high efficiency filters, so the air filtration level reaches 100000 (3μm).
Air capacity regulation		Frequency control to regulate the air capacity.
Heating method		Electrical heating, heater material to be SUS304
Control method		PLC control, frequency converter regulating the air capacity, touch screen operating system, Chinese operation interface.
Controlled silicon		Famous brand with high temperature control precision.
GMP standard		Designed and manufactured according to GMP standard, in accordance with GMP requirements.
Product standard		According to JB/T13755-92 standard
Machine dimension		Refer to the installation drawing

Brief introduction of CIP one-way cleaning system
The cleaning machine consists of main frame, water pipeline, cleaning ball, high-pressure booster pump, control valve and control system. After quick-connecting the water inlet of cleaning machine with customer’s water inlet pipe, start the cleaning procedure to finish this process automatically.

Sample

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