English
If you've ever worked with powder blends for tablet compression, you know the struggle—poor flow, segregation, and dust are constant headaches. Wet granulation isn't just about sticking particles together; it's a precision engineering process that transforms problematic powders into free-flowing, uniform granules. This guide walks you through the entire wet granulation workflow, from raw material milling and high-shear mixing to fluid bed drying and final lubrication. We'll cut through the theory and focus on the critical control points—binder addition rate, granulation endpoint, and drying curves—that separate a robust process from a failed batch.
Based on actual production validation data, this article systematically outlines the complete operational workflow for high-efficiency coating machines, covering everything from equipment preparation, preheating, and air purging to parameter setting and process control. Focusing on tablet bed temperature as the core control variable, the article details the dynamic equilibrium among inlet air temperature, spray liquid flow rate (peristaltic pump speed), atomization air pressure, pan negative pressure, and coating pan rotation speed, while providing clear logic for parameter adjustment and real-time decision-making strategies.
Recently, a complete integrated production line for wet granulation and fluid bed drying, customized for a Polish pharmaceutical manufacturer, has fully passed Factory Acceptance Test (FAT) and is ready for shipment to the customer’s facility in Europe.This turnkey solid dosage processing line consi
This article introduces the operating principles of the air purification system in a coating machine, as well as how to maintain that filtration system.
